Endocrine Abstracts

Introduction: The common causes of thyrotoxicosis are Graves’ disease, toxic multinodular goitre and toxic adenoma which account for >90% of cases of this condition. Iodine-induced thyrotoxicosis (Jod-Basedow syndrome) is infrequently considered as a cause of thyrotoxicosis. This case describes a lesser known cause of iodinated contrast-induced thyrotoxicosis.Case Report: A 47 year old man with known alcoholic liver disease and recurrent pancrea...

Background: Patients with adrenal incidentaloma (AI) and cortisol levels of 50-138 nmol/l on overnight dexamethasone suppression tests (ONDST) may have “mild autonomous cortisol secretion” (MACS). MACS is associated with increased morbidity, including osteoporosis, but this is infrequently systematically evaluated. We compared fracture risk and fracture prevalence in patients with AI, both with and without MACS.Methods: Data were collected retr...

Case history: A 74-year old gentleman was referred from Urology clinic for hypercalcemia after being treated for left vesico-ureteric calculus causing mild hydronephrosis. Past medical history included asthma, eczema and hypertension. He had been taking calcium supplements for 5 years, but stopped 2 months prior to clinic. He was asymptomatic and quite well with no recent fracture.Investigations: Adjusted Ca ranged from 2.62 to 2.78 mmol/l, PTH from 2.6 ...

A 59-year-old male patient, who is fit and well, presented with abdominal discomfort, night sweats, back pain and lower urinary tract symptoms. The CT scan, organised by the GP, demonstrated a 17 cm heterogenous mass with central necrosis and scattered calcification in right side of abdomen, possibly right adrenal origin or liver or kidney. He was referred to Adrenal MDT. Baseline functional testing showed unsuppressed cortisol level in an overnight dexamethasone, high DHEA su...

Background: Following vaccination for SARS-CoV-2 a significant proportion of individuals experience moderate to severe symptoms. In patients with adrenal insufficiency (AI) this has been reported to translate in to need for increased glucocorticoids and incipient or frank adrenal crises. We assessed occurrence of symptoms, need for glucocorticoid dose adjustment and crises in a large cohort of patients with AI following vaccination for SARS-CoV-2.Methods...